Direct vascular damage at the time of injury leads to dysfunction of the blood brain barrier (BBB) and this is thought to be integral to the development of coagulopathy
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5d,e,k,m and 8a,h were created using BioRender (BioRender.com)
Also, avoid it if you are allergic to benzyl alcohol, a preservative found in glutathione supplements
The incorporation dates of these measures are reflected in Table 67

Abbreviations Used 3MP 3-mercaptopyruvate 3MST 3-mercaptopyruvate sulfurtransferase AMPA alpha-amino-3-hydroxy-5-methy-4 isoxazole proprionic acid ATP adenosine triphosphate CAT cysteine aminotransferase CBS cystathionine -synthase CSE cystathionine -lyase DHLA dihydrolipoic acid DTT dithiothreitol elF2 eukaryotic translational initiation factor 2 alpha ER endoplasmic reticulum GABA -aminobutyric acid H 2 S hydrogen sulfide NADH (NAD) nicotinamide adenine dinucleotide NADPH nicotinamide adenine dinucleotide phosphate NaHS sodium hydrosulfide NMDA N -methyl-d-aspartate NO nitric oxide Nrf2 nuclear factor erythroid 2-related factor 2 PERK protein kinase-like ER kinase PLP pyridoxal 5-phosphate ROS reactive oxygen species RPS3 ribosomal protein S3 STAT3 signal transducers and activators of transcription 3 TNF- tumor necrosis factor- TRP transient receptor potential UPR unfolded protein response V-ATPase vacuolar-type proton ATPase Acknowledgments This work was supported by a grant from the National Institute of Neuroscience and KAKENHI (23659089) from Grant-in-Aid for Challenging Exploratory Research to H.K
