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We discuss how ME/CFS emerges from an intricate web of genetic vulnerabilities and environmental triggers, notably viral infections, leading to a complex series of pathological responses including immune dysregulation, chronic inflammation, gut dysbiosis, and metabolic disturbances

10.1073/pnas.95.11.6448 Proc

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The presurgical visit occurred approximately 1 month before the DBS surgery, whereas the post-surgical visits occurred at 1, 3, 6 and 12 months after surgery