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Because no controlled human trials exist, especially in female populations, much of the conversation is based on speculation, anecdote, and animal data

Within this mechanistic framework, natural compounds with antioxidant and anti-inflammatory properties, including vitamins C and E, glutathione precursors, CoQ10, L-carnosine, polyphenols including quercetin, resveratrol, and curcumin, and saffron metabolites like crocin and safranal show biological plausibility and preliminary efficacy on biochemical and behavioral endpoints

Calreticulin's role(s) in autoimmune disorders

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Its anti-fibrotic action makes it particularly well-suited for study in models of chronic injury and cardiac fibrosis

[DOI] [PubMed] [Google Scholar] 60.Halabi Z., El Helou C., Al Balushi H., Gittinger M., Steck A.R., Kaakour A., Abu-Alfa A., El Zahran T