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Numerous researchers have found that individuals suffering from ME/CFS have a lower quality of life than people with other chronic illnesses, including multiple sclerosis (MS) (32), lung disease (33), rheumatoid arthritis (RA) (3335), and some forms of cancer (11, 33, 35)

Women of reproductive age, vegetarians, and people with gastrointestinal conditions that affect iron absorption face a higher risk

In normal fibroblasts, Myo-Ins induced a robust increase in mt-ND4, with no significant change at 0.1 mM and marked upregulation at 1 mM (2.33-fold) and 5 mM (3.06-fold) (Fig

Moreover, individual genetic variations in mitochondrial or E2-responsive genes, such as ESR1, TFAM, PGC-1 and NRF1, may influence mitochondrial biogenesis, redox regulation and susceptibility to hormonal decline (136)

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