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The negative results of the clinical trials with antioxidants prompted new studies focusing on the mechanisms of oxidative stress in diabetes in order to develop causal antioxidant therapy

The skin attributes improved at 12 weeks (as assessed by blind expert graders) for elasticity, wrinkles, and evenness in different body areas (face, hands, neck, etc.) compared with placebo measurements

many of the same cytokines can trigger production of ROS from the mitochondria and other oxidative organelles in cells, a self-perpetuating cycle

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