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Moreover, ROS stimulate the expression and activation of MMPs, particularly MMP-1 and MMP-13, in synovial cells (Kwapisz et al., 2023)

[7] Clinicians should exercise extreme caution in advanced chronic kidney disease or sarcoidosis, tuberculosis, and other granulomatous disorders where extrarenal 1-hydroxylase activity can generate excess calcitriol and precipitate hypercalcaemia even at modest serum 25-hydroxyvitamin D concentrations

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Zhang YL, Jia SY, Yang B, Miao J, Su C, Cui ZG, Yang LM, Guo JH