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We observed upregulation of DNMTs , but literature also reported increased protein levels and catalytic activity by interaction of DMSO with their enzymes substrates (DNA and AdoMet) 19,29,30

Massey V, Williams C (1965) On the reaction mechanism of yeast glutathione reductase

*Correspondence: Lingchen Tan, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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The extracellular signalingregulated kinase (ERK) pathway is the most prominent and clinically utilized target, while the Jun N-terminal kinase (JNK) pathway and p38 pathway play critical modulatory roles in cancer cells