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Description

The MHRA advises that metformin commonly reduces B12 levels and recommends testing if deficiency is suspected (for example, in patients with anaemia or neuropathy) and considering periodic monitoring in people with risk factors such as higher doses, longer duration of treatment, or other risk factors for deficiency

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Maximum results occur during weeks 10-16 when both compounds are at optimized doses

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However, recent perspectives suggest that moDCs may not be the most optimal DC subtype for vaccination ( + T cell responses and may instead contribute to immune regulation or tolerance in cancer settings (Wculek et al., 2020)

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