MC-Val-Cit-PAB(m-PEG8)-Exatecan m-peg4 3-benzodiazole Synonyms CAS Number n/a
MC-Val-Cit-PAB(m-PEG8)-Exatecan m-peg4 3-benzodiazole Synonyms CAS Number n/aSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures,
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