foxo4-dri cancer Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging The disordered p53 transactivation domain
The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4 DRI Nature Communications FOXO4 DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53 serine 15 phosphorylation Communications Biology foxo4 dri peptide senolytic 2023 study Molecular modelling of the FOXO4 TP53 interaction to design peptides for the elimination of senescent cancer cells FOXO4 DRI induces keloid senescent fibroblast Senolytic Peptide FOXO4 DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes PMC FOXO4 DRI regulates endothelial cell senescence via the P53 signaling pathway PMC Development of a novel senolytic by precise disruption of FOXO4 p53 complex eBioMedicine
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