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An Evidence-Based Approach to Anticoagulation Therapy Comparing Direct Oral Anticoagulants and Vitamin K Antagonists in Patients With Atrial Fibrillation and Bioprosthetic Valves: A Systematic Review, Meta-Analysis, and Network Meta-Analysis

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Direct or indirect indices of progesterone production: Urinary or serum luteinizing hormone (LH) rise A rise in basal body temperature Increase in serum progesterone Menstruation following a shift in basal body temperature Sonographic evidence of ovulation: Collapsed follicle Fluid in the cul-de-sac Features consistent with corpus luteum formation Secretory endometrium 6 ADVERSE REACTIONS The following serious adverse reactions are discussed elsewhere in the labeling: Hypersensitivity Reactions and Anaphylaxis [see Warnings and Precautions (5.1)] Ovarian Hyperstimulation Syndrome [see Warnings and Precautions (5.2)] Pulmonary and Vascular Complication [see Warnings and Precautions (5.3)] Ovarian Torsion [see Warnings and Precautions (5.4)] Abnormal Ovarian Enlargement [see Warnings and Precautions (5.5)] Multi-fetal Gestation and Birth [see Warnings and Precautions (5.6)] Embryofetal Toxicity [see Warnings and Precautions (5.7)] Ectopic Pregnancy [see Warnings and Precautions (5.8)] Spontaneous Abortion [see Warnings and Precautions (5.9)] Ovarian Neoplasms [see Warnings and Precautions (5.10)] 6.1 Clinical Study Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trial of another drug and may not reflect the rates observed in practice