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ROC analysis of adduct levels in serum from patients known to have APAP hepatotoxicity showed that an APAP protein adduct level 1.1 nmol/mL had a high sensitivity and specificity (96.8 and 95.0 %, respectively) for patients with APAP overdose and ALT levels above 1000 IU/L

The increased hypersynchrony in our AD-tau cultures suggests that seeded tau inclusions in a subset of neurons are sufficient to alter normal network activity

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Additionally, having established that HFD-Taf12L can interact with Taf4, we wanted to look for the sufficiency of HFDs in the heterodimerization and specificity of Ca TAF12 variants