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Abbreviations ACS: Acute coronary syndrome AF: Atrial fibrillation ASO: Antisense oligonucleotide ATE: Arterial thromboembolic events CKD: Chronic kidney disease CRP: C-reactive protein DOAC: Direct oral anticoagulant DNA: Deoxyribonucleic acid ESRD: End-stage renal disease HR: Hazard ratio IV: Intravenous LMWH: Low molecular weight heparin MDC: Monodansylcadaverine MI: Myocardial infarction mRNA: Messenger RNA NOAC: Novel oral anticoagulant PCI: Percutaneous coronary intervention RNA: Ribonucleic acid TF: Tissue factor TIA: Transient ischemic attack VTE: Venous thromboembolic events References Gmez-Outes A, Surez-Gea ML, Calvo-Rojas G et al (2012) Discovery of anticoagulant drugs: a historical perspective