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Anodal tDCS stimulation of the DLPFC increases local cerebral blood flow perfusion, enhances synaptic neurotransmitter release and transmission, strengthens functional connectivity within cortical neural networks, and promotes executive function recovery (Longfei et al., 2025)

1 H NMR (400 MHz, DMSO- d 6 ) 12.44 (s, 1H), 11.13 (s, 1H), 9.98 (s, 1H), 7.78 (dt, J = 16.5, 8.1 Hz, 2H), 7.64 (d, J = 7.0 Hz, 1H), 7.41 (d, J = 3.4 Hz, 1H), 6.73 (d, J = 6.5 Hz, 1H), 5.12 (dd, J = 12.7, 5.4 Hz, 1H), 4.04 (d, J = 19.6 Hz, 2H), 3.53 (d, J = 10.5 Hz, 2H), 3.15 (t, J = 7.1 Hz, 2H), 3.062.98 (m, 2H), 2.962.83 (m, 3H), 2.74 (dd, J = 21.0, 9.4 Hz, 1H), 2.60 (d, J = 19.4 Hz, 1H), 2.572.52 (m, 1H), 2.091.87 (m, 5H), 1.68 (d, J = 6.8 Hz, 4H), 1.47 (s, 2H), 1.33 (s, 4H), 1.21 (d, J = 17.8 Hz, 9H)

However, unlike the animal findings, these trends were not consistently reproduced in human studies (88, 89)

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