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doi: 10.1002/lt.23370

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it provides necessary help for the growth, metabolism, and biosynthesis of tumor cells, immune cells, and nonimmune cells in the TME and also assists with the regulation and maintenance of the TME

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A substance with a molecular weight below 400 Daltons can diffuse unhindered, whereas a larger molecule exceeding 1,000 Daltons may encounter obstruction within the mucus layer