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Makimura H, Feldpausch MN, Rope AM, Hemphill LC, Torriani M, Lee H, et al

Dosage adjustments often become necessary with oral forms to compensate for reduced bioavailability, which can introduce variability and complexity into research

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The calorie restriction-induced modulations have been demonstrated in organisms ranging from yeast to mammals

In preclinical mouse models, MOTS-C administration prevented body weight gain of approximately 1520% in high-fat-diet cohorts compared with untreated controls (Lee et al., 2015

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