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This approach would ensure that interventions are both effective and safe, addressing the variability in drug responses among patients (187)

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In summary, although most studies of "subjective" symptoms suggest a beneficial effect of L-carnitine supplementation for maintenance dialysis patients, the Work Group concluded that the heterogeneity of study design, and the difficulty in measuring these and related symptoms in an unbiased manner render the available evidence in this area inconclusive

Nature Cell Biology , 15 (6), 637646