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Growing evidence indicates that PGRN regulates multiple aspects of lysosomal function, including cathepsin and GCase activities and lysosomal pH 40,170

Furthermore, the studies so far have mostly considered only a single optimization criterion: sustainability or cost

The final models were validated using Molprobity 43 , with the final statistics for data collection, structure determination, and refinement given in Supplementary Table 1

Man-LA achieves active brain delivery through mannose recognition of GLUT1 expressed on brain endothelium and astrocytes

Beij A., Verdonk R