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In contrast, knockdown of RRM2 significantly inhibited the migration and invasion ability of THCA cells compared with the control group ( Figure 7C , Supplementary Figure S6 )

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By loading Fer-1, an iron death inhibitor, into SSe@ZIF-8, FSZ nanoparticles showed stable drug release ability under acidic environment, and could be decompressed under oxidative stress to release SeNPs and Fer-1 with antioxidant properties

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