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Individuals with the 677T allele and the 1298AC genotype had a higher susceptibility to MS than those with the wild-type genotype [101]

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This makes the injections particularly effective for those with conditions like pernicious anemia or Crohns disease, where the body struggles to absorb B12 naturally

Additionally, individuals with active cancer are generally advised against NAD+ therapy due to theoretical risks of fueling cancer cell metabolism