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The primary findings were an increase in the incidence of subcutaneous fibrosarcomas in high-dose male rats receiving valproate and a dose-related trend for benign pulmonary adenomas in male mice receiving valproate

first compared the saRNA vaccine with an nr-mRNA vaccine head to head and demonstrated that the former achieved comparable efficacy at lower doses with extended expression period [87]

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107 In response to various stimulations, PDK1 can activate phosphoinositide-3 kinase (PI3K) and then Akt, playing pivotal roles in energy metabolism, cell proliferation and migration

Second, when different active metabolites focus on the same target, they trigger alternations in other pathways and thus regulate other targets

Kar R, Panchali T, Das P, Dutta A, Phoujdar M, Pradhan S