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Angiotensin IV is a derivative of the potent vasoconstrictor angiotensin II and has been shown to enhance acquisition, consolidation and recall of learning and memory in animal models when administered centrally or peripherally

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This insight has guided Fc-engineering of IgG variants with improved pH-dependent FcRn binding, resulting in antibodies with extended plasma half-life in human FcRn transgenic mice, non-human primates (NHPs) as well as humans 10,23,24,25

doi: 10.1016/j.neuroscience.2018.04.017 123