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Discovery of potent necroptosis inhibitors targeting RIPK1 kinase activity for the treatment of inflammatory disorder and cancer metastasis

The fifth is hypothetical based on animal cognitive testing

Increased fibrosis and interstitial fluid pressure in two different types of syngeneic murine carcinoma grown in integrin beta3-subunit deficient mice

Razandi M, Pedram A, Jordan VC, Fuqua S, Levin ER

Holleran, W.M

Although the SPH domain alone cannot activate c-MET, mutations that disrupting the interaction between HGF-SPH and c-MET-SEMA significantly reduce HGF-induced c-MET activation, validating the functional importance of this interaction 15