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The time to reach steady state for orforglipron is approximately 14-21 days of once-daily dosing, consistent with its terminal half-life

This leads to poor B12 absorption, even in those who consume sufficient dietary sources[11]

The irony, as you point out, is that this same rigidness does not apply to other medications that can be prescribed in a more flexible manner

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[27] Vitamin B 12 deficiency has the potential to influence methylation patterns in DNA, besides other epigenetic modulators such as micro (RNAs), leading to the altered expression of genes

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