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[1] [2] This expiration date applies when the medication has been continuously refrigerated at the appropriate temperature range and has never been frozen

When mitochondrial dysfunction occurs in cells, homeostasis is coordinating by mitophagy which balance a physiological response of mitochondrial biogenesis and clearance of damaged mitochondria (Luo et al., 2020)

L., Kim, K

Diabetologia 59 , 16451654 (2016)

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Untreated pyelonephritis progresses to sepsis in 10-20% of cases, particularly dangerous for pregnant women, diabetics, and immunocompromised patients who need immediate IV antibiotics