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Murphy and Levine, 2016), and interestingly, an equivalent number of proteins (~ 200) are predicted to contain either a conventional or a Phospho-FFAT motif (Di Mattia et al, 2020a)

To this end we used dicoumarol, a potent inhibitor of NQO1, which promotes the degradation of NQO1-protected proteins, such as p53 (18)

One key difference: tirzepatide is a dual GIP/GLP-1 receptor agonist, while semaglutide targets only GLP-1