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Studies have demonstrated that quercetin supports the clearance of senescent cells, and in clinical trials, quercetin and fisetin have been shown to boost each others effects [1][2]

although several candidate genes such as MAP4K4, E2F6 , and UBE2N have demonstrated preclinical promise, their translation into clinical settings remains at an early stage, highlighting the need for further in vivo validation and tumor-specific delivery strategies

The median weight difference between the first and second visit was 1.8 kg (2.02%) in the CR group and 0.05 kg (0.04%) in the control group ( p = 0.013 for absolute changes, 0.011 for relative changes) (Fig

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