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In addition, significantly increased activity of all four mutant variants of Nedd4-2 is also evident from the results of fluorescence-based autoubiquitination assay (Supplementary Fig

Statistically insignificant variability in lipid composition is observed for lipid droplets within a single worm

Loss of AMPK activity induces organelle dysfunction and oxidative stress during oocyte aging

The presence of the D1236 (from MRP2 substitution) instead of G1228 (wild-type MRP1) in the chimera M8 could create a steric hindrance, as shown by the Cryo-EM apo and LTC 4 bound (inward-facing) structures of bovine MRP1 40,44 (Fig