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doi: 10.1016/j.cell.2021.09.009 9

In renal cell carcinoma (RCC), Rh4 induces ferroptosis primarily via the NRF2 pathway ( Andrographolide, the primary bioactive component of Andrographis paniculata , is a diterpenoid lactone with potent anticancer activity

A similar approach has also been used to prolong the shelf life of vegetative tissue of vegetables, such as for example broccoli ( Transgenic approaches that silence ACO expression are also beneficial in floriculture