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This dual specificity was not surprising as HxlR responds to both FA and MG in Bacillus subtilis 15 , and indeed it sparks interesting biological questions, such as what is the relationship between FA and MG metabolisms, and whether it is possible to split FA from MG HxlR specificity, thus creating unique specific sensors for each of these aldehydes

Controlled studies have shown that acetaldehyde causes skin flushing, dizziness, increased heartbeat, nausea and headaches

These studies suggest that in the future, regulating DN from the perspective of iron cell death may provide new insights for the treatment of diabetic kidney disease

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doi: 10.1155/2022/8011850 124 BoirieY

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