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Valproyl metabolites trap mitochondrial CoA which leads to decreased ATP production, further depleting carnitine since ATP is needed for the carnitine transporter to work

Citations Citations to this article as recorded by Pharmacokinetics of a single-pill combination of rosuvastatin and ezetimibe (2.5 mg/10 mg) in healthy Chinese subjects: an open-label, two-period, phase I study Ying Wang, Jiaxiang Ding, Dongmei Cheng, Yuzhou Ding, Tonghao Zhang, Wang Hu, Xiaoni Wang, Xu Zhu, Yunqiu Xie, Huan Zhou Naunyn-Schmiedeberg's Archives of Pharmacology.2026

In obese mice with PCOS, hyperandrogenemia is strongly associated with the disruption of mitochondrial structure in the oocytes (134)