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Description

Following cardiac or cerebral ischemia, with rapid depletion of oxygen and nutrients, there are elevated levels of intracellular Ca 2+ and increased oxidative stress, changes that promote the opening of mPTP [55]

doi: 10.1371/journal.pone.0132421 36 SteinE

10.1210/edrv-16-4-427 203 RellingerE

MacClellanLRHowardTDColeJWStineOCGilesWHO'ConnellJRet al

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L-Nle was preferred in the N-terminal for optimal inhibition and zinc coordination to the oxygen of the benzamide function is estimated to allow the lipophilic P1 substituent to be easily accommodated in the S1 pocket