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However, in the complex molecular processes that characterize tumorigenesis, iron also plays a central role in ferroptosis, a form of non-apoptotic regulated cell death characterized by the lethal accumulation of lipid peroxidation products and ROS derived from iron metabolism (362, 363)

Unfortunately, as reviewed by van der Wielen and co-authors (75), most studies analyzing the expression of amino acid transporters were performed at the transcriptional level, not ensuring the expression of the functional protein and not allowing the evaluation of the cellular localization of these receptors

Interestingly, these effects closely resembled those of imipramine, a tricyclic antidepressant drug [32, 33]

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Proton Beam Implementation and Physics Research at MDACC

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