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The expression of AKT, a set of three serine/threonine-specific protein kinases, is high in the liver

Rb et al., 2017

Miller et al., 2014)

Because people who have difficulty absorbing vitamin B12 from food absorb free vitamin B12 normally, their vitamin B12 deficiency tends to be less severe than that of individuals with pernicious anemia, who cannot absorb either food-bound or free vitamin B12

Kranner I, Birti S, Anderson KM, Pritchard HW

Despite this, the anti-tumor efficacy of PLD is still limited due to low stability, insufficient availability, or uncontrolled and inadequate release of the encapsulated drug at the tumor site 6,7