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A combined donepezilmemantine drug with the brand name Namzaric was approved by the FDA in 2014 for the treatment of moderate-to-severe AD in people who are taking donepezil hydrochloride at the recommended clinically efficient dose of 10 mg/day ( AD report)

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NF-B activation upregulates genes involved in cell survival and proliferation, such as PUMA, leading to epithelial cell apoptosis and contributing to UC development (100)

doi: 10.1016/j.expneurol.2015.09.019 [DOI] [PubMed] [Google Scholar] 21.Deflorio C, Onesti E, Lauro CA-O, Lauro C, Tartaglia G, Giovannelli A, et al