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These individuals may experience abrupt elevations in alanine aminotransferase (ALT) levels exceeding 1,000 U/L within 14 months of use, often accompanied by autoimmune hepatitis-like features

This clarification step is crucial to prevent clogging of the affinity column and to enhance the efficiency of the purification process

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doi: 10.1016/j.drup.2021.100787 232 DangEVBarbiJYangH-YJinasenaDYuHZhengYet al

Studies in structured and preclinical models have shown that changes in this pathway can influence lipid metabolism indicators, mitochondrial activity markers, and energy balance signals under standardized conditions