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14 reported that oxidative environment induces T-cell hyporesponsiveness through inhibition of PLC activation induced by T-cell receptor stimulation

10.1017/S0007114517000885 21 ButelM.-J

Acknowledgements B.M

95% CI: 1.84, 6.95

Monocytic ROS production slightly decreased, and several mitochondrial ETC-related genes showed significant alterations in monocytes that responded to IFN-beta treatment compared to non-responders [121, 122]

Natural compounds such as piperlongumine and cotylenin A exhibit synergistic therapeutic efficacy with SAS, which suggest that the triple combined treatment with piperlongumine, piperlongumine and SAS is highly effective against pancreatic cancer (Kasukabe et al., 2016