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Immune Dysfunction in Acute Undernutrition: Driver of Acute and Chronic Disease Outcomes Immune dysfunction in SAM predisposes children to acute infections including enteric and respiratory illnesses, measles and malaria, while survivors experience growth failure and long-term metabolic disorders [104,105,106] Both acute undernutrition and obesity precipitate micronutrient insufficiency, which exacerbates the severity of these conditions in mutually reinforcing cycles [51, 107,108,109] Enteropathy, characterized by gut mucosal degeneration, villous atrophy and impaired gut structure, occurs through a cascade of nutrient deficiency-induced biochemical, physiological and histological changes [108, 109]

Vitamin B12 injections, typically hydroxocobalamin in the UK, are prescribed to treat or prevent B12 deficiency, supporting red blood cell formation and neurological function

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This isn't universally practiced, and the evidence for cycling versus continuous use is based on clinical preference rather than comparative trial data

What biomarkers reliably measure senescent cell clearance in humans

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