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It cooperates with RORt and ROR to drive IL17A expression, and its deficiency causes a defect in Th17 differentiation and a resistance to EAE (97)

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RA pathogenesis also critically involves autoantibodies, including rheumatoid factors and anticitrullinated protein antibodies, characteristically present in the blood and joint fluid of RA patients [119]

Some users ceased because they perceived no benefit after six weeks