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While early safety data appear favorable, the potential for proangiogenic activity to influence oncogenic processes underscores the importance of comprehensive cancer pre-screening prior to therapeutic use

E., Schor A

Hidaka T, Hata T, Soga J, Nakamura S, Fujii Y, Idei N, Fujimura N, Nishioka K, Kihara Y, Chayama K, Noma K, Liao JK, Higashi Y

Devoid of the multi-layered smooth muscle and elastic fibers characteristic of normal vessels, these abnormal vessels not only fail to effectively alleviate hypoxia but exacerbate tissue edema through increased vascular leakage

Pyrrolizidine Alkaloids-Containing Chinese Medicines in the Chinese Pharmacopoeia and Related Safety Concerns