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State Medicaid programs may issue temporary billing instructions tied to newly approved drugs, as NC Medicaid did for Igalmi

This is the window that the Finkley 2005 trial captured, and the Carey/Pickart ultrasound work confirmed at the structural level: an average 28% increase in collagen density, with top responders at 51%

The metabolic benefits extend to cellular energy regulation, where NNMT inhibition increases intracellular NAD+ levels by 1.2-1.6 fold