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This upregulation was also reflected in increased GSH levels (Fig

Int J Zool Appl Biosci 8(4):19

Various low-molecular-weight endogenous non-enzymatic antioxidants are found in animal and human tissues

Nrf2, upon translocating to the nucleus, binds to antioxidant response elements (AREs) located in the promoter regions of various genes ( Figure 3 ) ( Figure 3 4.1 Bioactive compounds boost antioxidant and anti-inflammatory responses by activating Nrf2/KEAP1 signaling to combat mastitis: in vitro evidence It has been well established through in vitro experiments that bioactive compounds can enhance the activation of the Nrf2/KEAP1 signaling pathway

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