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Further, because the functional cells of the pancreas (both exocrine acini and endocrine islets) are highly secretory, FGF21 plays a protective role by enhancing the response to ER stress via activation of the UPR (189, 259)

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Choline-related: High choline intake can cause a fishy body odor, sweating, gastrointestinal upset and, at very high doses, low blood pressure dose-dependent and more relevant to oral loading than to small injected volumes [1]