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Notably, some agents may possess nasal mucosa toxicity, thus, the toxicity evaluation is needed before intranasal administration

Zhang T, Zhang M, Cui S, Liang W, Jia Z, Guo F, Ou W, Wu Y, Zhang S (2023) The core of maintaining neuropathic pain: crosstalk between glial cells and neurons (neural cell crosstalk at spinal cord)

However, recent results from STEADY-PD III (NCT02168842, Table 2), a 36-month, multicenter, randomized, parallel-group, placebo-controlled trial (Investigators 2020) demonstrated no significant clinical effect of isradipine in progression of early-stage PD, measured as the change of MDS-UPDRS part I to III score in the ON medication state, from baseline to 36 months

10.3858/emm.2012.44.11.073 Exper

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