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Lancet 349 , 1447 (1997)

(r)-3-hydroxy-4-trimethylammoniobutyrate 78

doi: 10.1007/s00702-019-02138-1 386 ErcanbrackWSRamirezMDunganAGaulEErcanbrackSJWingertRA

Mitochondria are both the primary site of ROS formation and a critical target of the oxidative damage, that amplifies ROS production, triggers the activation of caspases and leads to neuronal apoptosis