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Alterations in the gut microbiota throughout this time precipitate the onset of chronic disorders such as asthma, allergies, and obesity in both adulthood and childhood (505, 506)

Pax-6 expression and activity are induced in the reepithelializing cornea and control activity of the transcriptional promoter for matrix metalloproteinase gelatinase B

In conclusion, UCH-L1, USP22, OTUD5, and USP14 are promising therapeutic targets in DKD, but more clinical studies are needed to confirm safety and efficacy