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Their study showed decreased production of methyltransferase Ezh2 in the atria of aged mice with AF [Figure 6] and unveiled that Ezh2 restored H3K27me3 levels in the promoter regions of CDKN2a and Timp4 genes in primary mouse atrial fibroblasts at late passages, preventing senescence development and alleviating profibrotic effects [156]

We welcome contributions on: Parentchild and peer synchrony Inter-individual covariation in neural, emotional, or behavioral domains Geneenvironment interactions Internalizing & externalizing difficulties CU traits, emotion regulation, aggression, bullying Transactional, longitudinal, multimodal approaches Innovations in dyadic measurement and modeling Deadlines Manuscript Summary: 20 March 2026 Manuscript Submission: 30 June 2026 Research Topic Editors: Prof

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This imbalance may be associated with increased mitochondrial load , decreased energy, and disruption of the natural balance within cells