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[Abstract]2020 Jan;24(2):1599-1613

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doi: 10.1155/2020/4356386 234 SongC.ZhangY.ChengL.ShiM.LiX.ZhangL.et al

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275 , L80L86 (1998)

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Beyond the canonical GPX4-glutathione (GSH) axis, recent studies have identified additional protective mechanisms such as ferroptosis suppressor protein 1 (FSP1), guanosine triphosphate cyclohydrolase 1 (GCH1), and mitochondrial dihydroorotate dehydrogenase (DHODH), which provide complementary safeguards against ferroptotic death

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The treatment specifically inhibits expression of key glycolytic enzymes, including hexokinase 2 and pyruvate kinase M2

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