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notably, novel nanomaterials targeting excessive iron in tumor cells to trigger ferroptosis open innovative avenues for RCC intervention

A 2025 review in Pharmaceuticals put it bluntly: There are obvious differences between the physiologies of rodents and humans

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Abstract Ferroptosis is an iron-dependent programmed cell death process that involves lipid oxidation via the Fenton reaction to produce lipid peroxides, causing disruption of the lipid bilayer, which is essential for cellular survival