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The concept of lysosomal membrane permeabilization (LMP) was first described in vitro in the oxidative stress-induced apoptosis of cultured glioma cells by llinger and Brunk (1995), Roberg and llinger (1998), and in vivo in the delayed necrosis of the hippocampal CA1 neurons (Yamashima et al., 1996, 1998, 2023

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the amino acid changes also may alter post-translational processes of the antibody constructs, such as changing the number or position of glycosylation sites

Furthermore, when cells are subjected to stress stimuli associated with cellular proptosis, they activate heat shock factor 1 (117), thereby promoting the expression of heat shock proteins, such as HSP70 (118)

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10.1016/j.msec.2019.03.086 62 GoeldnerC.ReissD.WichmannJ.MezianeH.KiefferB